منابع مشابه
Cefotaxime and desacetyl cefotaxime in human bile.
In a previous paper we reported on the determination of cefotaxime and desacetyl cefotaxime in human and rat serum after an i.v. injection of this cephalosporin (1); the concentrations of the parent compound and its metabolite in human bile were also briefly described. It has been shown that older cephalosporins with a 3~ acetoxymethyl substituent, e. g. cephalothin, are metabolised to the resp...
متن کاملPharmacokinetics of cefotaxime.
The pharmacokinetics of cefotaxime after intramuscular injection and intravenous infusion were determined. The mean peak serum level after the 500-mg intramuscular dose was 11.7 micrograms/ml, and it was 20.5 micrograms/ml after a 1,000-mg dose. The serum half-life was 1.2 and 1.3 h, respectively for the two doses. The apparent fractional volumes of distribution of 32 and 37 liters were not sig...
متن کاملDbltm Cefotaxime Sodium for Injection
The following organisms have shown in vitro sensitivity to DBLTM Cefotaxime Sodium for Injection. Gram-positive: Staphylococci spp, including coagulase-positive, coagulase-negative and penicillinase-producing strains. Streptococci spp, including β-haemolytic and other streptococci such as Streptococcus mitis (viridans), Streptococcus pneumoniae. (Many strains of enterococci, e.g. Streptoco...
متن کاملDisposition of cefotaxime and desacetyl cefotaxime during continuous ambulatory peritoneal dialysis.
The disposition of cefotaxime (CTX) and desacetyl cefotaxime (DAC) was studied in eight noninfected patients on continuous ambulatory peritoneal dialysis. Each patient received a single intravenous (i.v.) infusion and an intraperitoneal (i.p.) instillation of 2 g of CTX. Multiple blood and dialysate samples were collected during the 72-h period after drug administration. The half-life, steady-s...
متن کاملEvaluation of cefotaxime and desacetylcefotaxime concentrations in cord blood after intrapartum prophylaxis with cefotaxime.
Preterm premature rupture of the membranes is associated with a high risk of neonatal sepsis. An increase in the incidence of early-onset neonatal sepsis due to ampicillin-resistant Escherichia coli in premature infants has been observed in the past few years. Intrapartum prophylaxis with ampicillin has proven to be efficient for the prevention of early neonatal sepsis due to group B streptococ...
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ژورنال
عنوان ژورنال: The Clinical Investigator
سال: 1993
ISSN: 0941-0198,1432-1440
DOI: 10.1007/bf00180000